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By promoting autophagy via the mitogen-activated protein kinases signaling pathway, PNO1 mainly affects the levels of intracellular glutamate, which activates system Xc- to import additional cysteine
Information retrieval Information retrieval was performed using the following electronic databases: Embase, Medline, Cinahl, Scopus, Web of Science and International Pharmaceutical Abstracts (search terms in the Supplementary On-line Material)
doi: 10.1016/j.fct.2013.09.025 62 McGillM
Naturally produced in every cell of the human body, glutathione is a tripeptide composed of three amino acids glutamine, cysteine, and glycine and it serves as the master regulator of cellular redox balance, detoxification, immune function, and oxidative stress defence
doi: 10.1111/jdi.13576 4 GuariguataLWhitingDRHambletonIBeagleyJLinnenkampUShawJE
Acknowledgements This work was partly supported by Associazione Italiana Ricerca sul Cancro (AIRC) (IG2014-15197 to L.F.) and by grants from the University of Chieti-Pescara G
