JAMA 289 , 203209, (2003)
Infections Pneumonia Viral illness Sepsis Clinical Features Neonates: Neonatal jaundice (can be severe) Older children & adults: Sudden jaundice Dark tea-colored urine Fatigue, tachycardia Pallor Abdominal/back pain Hemolytic crisis after trigger exposure Confirmatory Test: G6PD enzyme assay (performed after hemolysis episode resolves) Pathognomonic Cells Heinz bodies denatured hemoglobin Bite cells result of splenic macrophage removal of Heinz bodies Management During Acute Hemolysis: Stop triggering drug/food Hydration Oxygen Treat infection Blood transfusion (if severe) Phototherapy/exchange transfusion in neonates Long-Term: Avoid triggers Vaccinations Genetic counseling Complications Acute hemolytic anemia Neonatal hyperbilirubinemia kernicterus Gallstones (pigment stones) Quick Mnemonic FAVISM F Fava beans A Aspirin / Antibiotics V Viral infections I Inherited X-linked S Sulfonamides M Malaria drugs (primaquine) Understanding G6PD Deficiency: Causes, Symptoms, and Management Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency: What is G6PD Deficiency
Although it is clear that IGF-IR confers resistance to molecularly targeted therapy, chemotherapy and radiotherapy, the complex IGF biology is a great challenge for targeting this pathway in cancer
Further Reading For additional peer-reviewed research on this topic, see: PubMed research on KPV anti-inflammatory activity
Braces helped some, but I was looking at months away from work
However, it is important to note that BPC-157 is not approved by the FDA for human use and is not available as an approved treatment at reputable medical practices, including ours
