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Severe vomiting or diarrhea can lead to dehydration, which may put your kidneys at risk of damage

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Weidinger C, Hegazy AN, Siegmund B

One the other hand, SGLT2 inhibitors specifically alter renal hemodynamics and then reduce intraglomerular pressure [21, 24,25,26], and attenuate diabetes-associated hyperfiltration and tubular hypertrophy, as well as reduce the tubular toxicity of glucose to directly protect kidney [27]

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Biomarkers and attention-deficit/hyperactivity disorder: A systematic review and meta-analyses