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Weekly formulations should be administered on the same day each week, while daily formulations should be given at approximately the same time each day

( 10.1016/j.atherosclerosis.2017.06.920) [DOI] [PubMed] [Google Scholar] 31.Chai W, Dong Z, Wang N, Wang W, Tao L, Cao W, Liu Z

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Among them, the action of incretin hormones, known as the incretin effect, contributes to 50% to 70% of insulin secretion after the oral ingestion of glucose in healthy subjects [1]

Just how much of a challenge this posed can be gauged from the fact that Mutt's group needed 10km of porcine small intestine to obtain about 1mg of pure secretin (Rehfeld 2012)