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A 2021 retrospective observational study cited in the PMC literature directly compared BPC-157 alone versus BPC-157 combined with TB-500 in a knee injection protocol and found the combination to be associated with improved outcomes providing the first head-to-head comparative observation of the two compounds used together versus independently

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However, the magnitude of VEGF change and the upstream signaling pathway driving it are not established with the precision needed to predict dose-response in humans