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Tumor-associated macrophages (TAMs), important immunosuppressive cells in the microenvironment, are able to activate the Gli2/IGF-2/ERK1/2 signaling axis to promote TGF- secretion and thus mediate the migration, invasion and EMT of hepatocellular carcinoma cells (Huh-7 cells) (73)

Coronary artery disease [Internet]

doi: 10.1016/j.juro.2013.08.080 [DOI] [PubMed] [Google Scholar] 51.Crivelli JJ, Yan PL, Shahinian V, Hsi RS, Hollingsworth JM

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The enhanced potency is due to the decreased binding of IGF1 LR3 to all known IGF binding proteins