T.SpencerC
A peptide may be sufficiently stable for controlled laboratory handling while still lacking validated human safety data
The data regarding electrophoretic mobility shift assays, nonenzymatic reaction between roGFP2 WT (SH) 2 and GSSG, thiol-specificity of the PfGrx-catalyzed reduction of roGFP2 WT (S 2 ), and rate constants at variable GSH concentrations are provided in the Supplementary Information
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PMCID: PMC6770193.
Gastrointestinal adverse events - predominantly nausea, vomiting, diarrhea, and constipation - are the most common class effects, occurring in 20%-60% of patients depending on the agent and dose, and are typically of mild-to-moderate severity, dose-dependent, and most prominent during titration