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In particular, these adducts repress the unduly stabilized -catenin from entering nucleus where it normally binds to TCF/LEF initiating the target gene transcription that encodes intrinsic promoting factors for tumour progression [121, 122]

Cardiovascular Disease: Insulin resistance is strongly associated with an increased risk of cardiovascular disease

The most important factors in assessing cardiac risk are the QT intervals, which are mediated by the flow of ions such as sodium, potassium, and calcium across receptors in the cell membrane (149)

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