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NNMT is an enzyme that converts nicotinamide to N-methylnicotinamide, consuming methyl groups and potentially reducing NAD+ availability

In most cases, this depletion takes place 3 to 4 months after starting this therapy

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Abnormal activation of the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has been associated with the onset of several inflammatory diseases, promoting various types of cell death, including apoptosis, necroptosis, and ferroptosis [178]