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doi: 10.1038/s41586-024-08412-x

This depot effect benefits shelf-life extension but necessitates higher initial loading to compensate for reduced bioavailability

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Some individuals may experience weight loss during the initial months of treatment, which may be related to nausea and decreased appetite

The article says individual variation in protein metabolism, amino acid absorption, and peptide pathway efficiency means standard recommendations do not suit everyone, and names baseline metabolic rate and muscle mass percentage as further variables

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