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Semaglutide injection involves the addition of a fatty acid side chain at the 26th position of the natural GLP-1 peptide chain, which can inhibit the degradation by DPP-4, thereby extending the half-life of semaglutide injection to one week 81

doi: 10.5644/ama2006-124.94

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Potential Side Effects of GIP/GLP1 Receptor Agonists Common side effects: Nausea, constipation, vomiting, diarrhea Fatigue, tiredness Altered taste Both medications may cause severe gastrointestinal issues such as gastroparesis, which can lead to hospitalization in some cases

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