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1 Supporting Data The approval for dato-DXd was supported by findings from 2 clinical trials: the Efficacy was evaluated in a pooled subgroup analysis of the TROPION-Lung05 and TROPION-Lung01 trials composed of 114 patients with locally advanced/metastatic EGFR -mutated NSCLC who had received prior EGFR-directed therapy and platinum-based chemotherapy

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In addition, given the cross-talk between microglia and astrocytes, this system could potentially activate A2 reactive astrocytes, which may help limit the excessive production of pro-inflammatory factors and oxidative stress molecules, ultimately restoring neural homeostasis

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In the meantime, anti-nausea medication, natural solutions like ginger or peppermint, and eating smaller meals can often help