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Esworthy RS, Aranda R, Martn MG (2001) Mice with combined disruption of Gpx1 and Gpx2 genes have colitis

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That is the accurate description, and it is much weaker than clinically studied. There is also a mechanistic argument buried in Ionescu & Frohman that deserves attention: 90 mcg/kg produced no significant additional response over 60 mcg/kg [5]