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Over the past several years, the company repositioned entirely around pemvidutide, its balanced dual GLP-1/glucagon receptor agonist for obesity and liver disease
doi: 10.1354/vp.43-6-1008
doi: 10.2174/138920006778017786 5 BruceE.Barlow-PayF.ShortR.Vilches-MoragaA.PriceA.McgovernA.et al
These phosphorylated R-SMADs dissociate from the receptor and form a trimeric complex with SMAD4, which translocates into the nucleus to regulate transcription of fibrosis-related genes, including -smooth muscle actin (-SMA) and collagen I [40, 41]
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