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However, this suggestion is consistent with studies in which the affinity of GLP-1R agonists at transfected human GLP-1R were studied (Sloop et al

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While these compounds show promise in preclinical studies, their safety and efficacy in humans remain to be established through proper clinical trials

364,365,366,367 These effects are mediated through multiple pathways, including transcriptional reprogramming 365 and the activation of SCFA-sensitive G protein-coupled receptors (GPCRs), such as GPR41 and GPR43

GIP Receptor Activation Glucose dependent insulinotropic polypeptide adds a second layer of metabolic regulation