Retatrutide is a synthetic 39-amino acid acylated peptide designed as a triple agonist targeting the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR)
Cao YY, Chen ZW, Gao YH, Wang XX, Ma JY, Chang SF, Qian JY, Ge JB
Ryan DH, Lingvay I, Deanfield J, Kahn SE, Barros E, Burguera B, Colhoun HM, Cercato C, Dicker D, Horn DB, et al: Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial
The most common side effects in trials are gastrointestinal: nausea (around 43% at 12 mg), vomiting (21%), and diarrhoea (33%)
In short, the GLp-1 patches are a scamthe science behind the GLP-1 molecules just doesnt allow for it to be delivered through the skin
In addition, the majority of people who stop taking GLP-1 drugs end up regaining the weight they may have lost