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This difference drives most of the gap in weight loss outcomes

Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions: potential for pharmacological interventions

Cravings may return at certain times, causing progress to stall

Combining two agents raises theoretical risk by extending drug exposure across multiple pathways simultaneously

doi: 10.3389/fneur.2023.1056341 Received 28 September 2022 Accepted 02 January 2023 Published 16 January 2023 Volume 14 - 2023 Edited by Jian-Quan Shi, Nanjing Medical University, China Reviewed by Tomas Marek, Mayo Clinic, United States

Most evidence comes from smaller Phase 1/2 studies and anecdotal research use