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ICER found the drugs deliver value at current prices but estimated that treating even 1 percent of eligible patients would exceed its $880 million annual budget impact threshold

A temporary strange or metallic taste in the mouth has also been noted in some cases immediately after injection, but this is not harmful

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COX-2 specific inhibitors (e.g., coxibs) preferentially reduce amounts of PGI2, tipping the balance toward thrombosis (Vonkeman 2010)