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As further consideration of translation of this therapeutic to the clinic, cochlear synaptopathy is implicated as a potential contributor to human tinnitus, although the published evidence is emerging and, so far, is largely indirect 11,60

The proton-motive force created by the ETC is also used for many additional mitochondrial processes, especially those related with transport across the IMM (Kulawiak et al., 2013)

As a control, cells were transfected with non-targeting siRNA (siCtr)

[CrossRef] [PubMed] [Google Scholar] Neuroprotective effects of metformin through the modulation of neuroinflammation and oxidative stress