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Importantly, this transcriptomic analysis demonstrated that 6 genes significantly altered in metformin-treated SW837 cells are complex I genes, a known target of metformin treatment, further supporting oxidative phosphorylation as a metabolic target of metformin treatment in rectal cancer

Given that ascites protects against ferroptosis despite this PUFA enrichment in the membrane, we considered whether other subcellular lipid compartments may contribute to ferroptosis protection

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Fruits and vegetables provide anthocyanins and carotenoids, some of which can cross the bloodbrain barrier or act through their metabolites to improve cerebral perfusion and activate endogenous antioxidant systems (163, 164)

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Medicare Part D coverage: Not commonly covered due to Medicare exclusions on weight loss medications