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The combination creates a dual mechanism: naltrexone reduces food reward and craving intensity, while bupropion enhances the brain's satiety signals and provides mild stimulant-like appetite suppression

They are also associated with different risks and interact differently with other drugs

2.1%, P=0.450) [38]

I felt like I needed to make a change, but due to severe arthritis from years of standing while teaching, I couldnt engage in physical exercise