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Along with tobacco smoking, type 2 diabetes mellitus, arterial hypertension, improper dietary habits, and insufficient physical activity leading to overweight and obesity, they are the primary modifiable risk factors of atherosclerosis and its most important complications, such as ischaemic heart disease, cerebral stroke, and peripheral artery disease [9]

With regard to the relationship between BDNF and depressive disorders, there is evidence that expression and activity of BDNF in the hippocampus are decreased in response to stress and increased by antidepressant treatment [40,41,42,43]

Zhou-Suckow Z, Duerr J, Hagner M, Agrawal R, Mall MA

Predictors of whole-body insulin sensitivity across ages and adiposity in adult humans