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Toxicology and applied pharmacology 257 , 338348, doi: 10.1016/j.taap.2011.09.017 (2011)

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J Clin Endocrinol Metab .

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Children under the age of two years are at a considerably increased risk of developing fatal hepatotoxicity, especially those on multiple anticonvulsants, those with congenital metabolic disorders, those with severe seizure disorders accompanied by mental retardation, and those with organic brain disease