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The standard titration schedule starts at 2.5 mg per week for 4 weeks, then increases to 5 mg per week for another 4 weeks, with subsequent increases of 2.5 mg every 4 weeks up to a maximum of 15 mg per week (Mounjaro prescribing information, Eli Lilly)
Still, the clear pattern seen with Wegovy and the higher risk in men suggest that doctors should monitor patients carefully, especially those receiving the higher doses for obesity
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Despite the growing presence of compounded GLP-1s, switching to branded alternatives remains rare
Common side effects dry mouth, insomnia, increased heart rate are manageable and improve over time
Both native GLP-1 and its analogs, including liraglutide and exenatide, exhibit similar inhibitory effects on platelet activation formation and thrombus
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