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Women are more likely to have Polycystic Ovary Syndrome (PCOS), central obesity, and thyroid issues

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This presents a major financial barrier for patients who cannot afford thousands of dollars upfront, even if it saves them money over the course of a year

COX-2 specific inhibitors (e.g., coxibs) preferentially reduce amounts of PGI2, tipping the balance toward thrombosis (Vonkeman 2010)