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A combination of protein misfolding, mitochondrial dysfunction, oxidative stress, neuroinflammation, and iron-mediated toxicity converge to disrupt neuronal homeostasis (Behl et al., 2022
Researchers designing combination protocols typically run controls with each compound in isolation alongside the combination arms to distinguish additive from synergistic effects and to identify which compound is driving each observed outcome
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Additionally, aPL stimulates the production of ROS in endothelial cells
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