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The main cerebral target for THC is type-1 cannabinoid receptors (CB1R), which are widely expressed in the brain and regulate various functions including neurotransmitter release, neuro-astroglial communication, and cellular bioenergetic processes [29,30,31,32]

Below is a list of some of the diseases and issues associated with glutathione deregulation or deficiency: Aging and related disorders Alzheimers disease Cancer (ovarian, bladder, etc.) Chronic liver disease Cognitive impairment Cystic fibrosis Diabetes, especially uncontrolled diabetes HIV/AIDS Hypertension Infertility in both men and women Lupus Mental health disorders Multiple sclerosis Neurodegenerative disorders Parkinsons disease Preeclampsia Ulcerative colitis There are some common polymorphisms or SNPs that impact glutathione and associated processes

Severe deficiency or neurological symptoms require injectable b12 for faster repletion

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