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Normally, oxidative stress leads to dissociation of Nrf2 from Keap1, its nuclear translocation, and activation of antioxidant response elements (ARE), but this axis is impaired in several ovarian pathologies including PCOS 79,80,81

Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1

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It: Lowers appetite Slows gastric emptying Improves blood sugar control It does not stimulate the central nervous system or raise alertness the way stimulant drugs such as phentermine do