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If your side effects are unpredictable, start with evening dosing for the first 4 to 6 weeks as you establish your dose
Extend your current dose step if: Nausea persists beyond 10 days at the current dose You are experiencing vomiting more than twice per week Diarrhea is disrupting daily activities You have lost significant amounts of food intake due to GI symptoms Your quality of life is substantially affected Stay at the current dose for an additional 2 to 4 weeks, then attempt the escalation again
If necessary, the dose can be further increased to 1 mg once a week after a minimum of four weeks on the 0.5 mg dose
You should discuss with your healthcare provider whether and how you should stop using tirzepatide before you plan to become pregnant
Westermark, P., Andersson, A
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