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Planegg, Germany) and analyzed by LC-MS/MS using an EvosepOne nanoLC (Evosep

Despite occupying a different location in static structures, Glu1 of exendin-P5 interacts with multiple residues that interact with His1 of the other peptides, including E364 6 .52 , E387 7 .42 , R310 5 .40 and W306 5 .36

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If additional glycemic control is needed after at least 30 days on the 7 mg dose, the dose can be increased to a maintenance dose of 14 mg once daily

Because this effect is directly related to blood glucose levels, it lowers the risk of hypoglycemia