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And in a remarkable mouse study published in Cell Metabolism in early 2026, researchers at the Chinese Academy of Sciences showed that semaglutide preserved cartilage and reduced joint inflammation in osteoarthritic mice even when pair-fed control mice lost the same amount of weight but showed continued cartilage deterioration

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Urolithin A protects human dermal fibroblasts from UVA-induced photoaging through NRF2 activation and mitophagy