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Key Takeaways Fat pad loss: Rapid weight loss from GLP-1 drugs can reduce natural fat pads in feet, causing pain and discomfort Prevention is crucial: Maintaining protein intake and resistance training helps preserve muscle and fat pad integrity Professional care helps: Early podiatric intervention can prevent complications and provide effective pain management Diabetic considerations: Patients with type 2 diabetes face additional risks including foot ulcers and neuropathy Treatment options exist: Custom orthotics, padding, and targeted therapies can restore foot comfort and function Understanding Ozempic Feet: The Medical Reality The term Ozempic feet describes foot-related complications that can occur when someone loses weight rapidly while taking GLP-1 medications such as Ozempic, Wegovy, or other similar drugs

PMCID: PMC2431115

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