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Operational and Technical Challenges: Recruitment: Enrollment of a specific patient population, particularly one that is heterogeneous (obese individuals and T2DM patients), may pose recruitment challenges

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Long-Term GLP-1 Use: What the Evidence Shows Three-year real-world data demonstrates that patients on continuous GLP-1 therapy maintain 75% to 85% of initial weight loss, compared to 0% to 25% maintenance after stopping

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A Realistic Weight-Loss Timeline Month 1 Many patients notice reduced appetite, fewer cravings, and improved portion awareness

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