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Keywords: Pycnogenol , pine bark extract, placebo-controlled, double-blind, antioxidant, anti-inflammatory, endothelial health, cardiovascular 1 Introduction There are many pine bark extracts on the market, from different pine tree species, from different countries and with different levels of efficacy for human health (14)

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doi: 10.3389/fphar.2025.1712903 Received 25 September 2025 Revised 17 November 2025 Accepted 05 December 2025 Published 08 January 2026 Volume 16 - 2025 Edited by Xiufang Huang, Guangzhou University of Chinese Medicine, China Reviewed by Adnan Amin, Yeungnam University, Republic of Korea Hua Yang, China Pharmaceutical University, China Updates Copyright 2026 Ma, Cao, Yang, Zhu, Wang, Liu, Chen, Liu and Zhang