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A formal mediation analysis in SELECT estimated that waist circumference reduction accounted for no more than 33% of the MACE effect
There are a lot of reasons that taking a GLP-1 can be a pain
And for those who titrate up to higher doses , the constipation can return or worsen with each dose increase
Severe or non-stop vomiting, or you can't keep fluids down (dehydration) Severe stomach pain, especially if it spreads to your back (possible pancreatitis) Upper-right belly pain, fever, or yellowing skin/eyes (gallbladder) Signs of an allergic reaction swelling, trouble breathing, a spreading rash These are class-wide GLP-1 warnings
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