The speed of response depends on factors including the severity and duration of deficiency, the presence of neurological complications, and individual metabolic differences
79,80 Extraintestinal manifestations can precede the diagnosis of IBD or develop later in the disease course
Common side effects of vitamin B12 injections include mild diarrhea, itching, nausea and vomiting, dizziness, headaches, and hot flashes
This is because issues with regular function of the gastrointestinal tract can prevent the proper release and absorption of the vitamin which causes deficiency
Vitamin B12 (cobalamin) is a water-soluble nutrient the body cannot produce on its own
MTHFR and Vitamin B12 Absorption The MTHFR genetic mutation has a negative effect on B12 absorption, with studies showing an increased prevalence of low blood levels of vitamin B12 in those with the mutation