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Common adverse reactions include local injection-site discomfort, redness, or swelling

Levodopa and cobalamin-related neurotoxic metabolites and benefits of COMT inhibitors The breakdown of LDopa through COMT requires methyl group transfer, leading to the formation of the stable compound 3-O-MethylDopa (Mller and Riederer 2023)

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Lancet ;398(10317): 2160-2172 View at Publisher | View at Google Scholar Frias JP, Deenadayalan S, Erichsen L, Knop FK, Lingvay I, et al