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Human trials need to define the product, route, dose, comparator, outcomes, adverse-event collection, and follow-up before those claims can be tested reliably

doi: 10.1016/j.yrtph.2015.06.016, 222

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C5 or C5a was utilized as a negative control as the Spiegelmer of the reverse AON-D21 sequence, RevAON-D21, is unable to bind any of them

b , Close-up view in this map shows density connecting helix 8 and G at the position of R419 of helix 8 and G310H311 of G