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Much of the focus is on obtaining a new indication for obesity for already FDA-approved diabetes medications such as Tirzepatide (Mounjaro) from Eli Lilly, which was recently approved for obesity under the brand name Zepbound

KLOW adds a fourth peptide, KPV, for enhanced anti-inflammatory action

But the glucagon-related adjustment does not, so skipping the titration entirely is not recommended

10.1016/S0197-4580(02)00065-9 16 BraidyN.BergJ.ClementJ.KhorshidiF.PoljakA.JayasenaT.et al (2019)

Sulfonylureas enhance exocytosis from pancreatic beta-cells by a mechanism that does not involve direct activation of protein kinase C