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The specificity of G6PD induced upregulation was attributed to increased histone hyperacetylation by histone acetyltransferases (HAT)s and increased HDAC, HAT, DNA polymerase II, and SP1 (transcription factor) binding to the G6PD core promoter (Figure 3)

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Effect of Sodium Glucose Cotransporter 2 Inhibitors on Cardiac Function and Cardiovascular Outcome: A Systematic Review