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Considering the significantly elevated expression levels of GLP-1R in diabetic patients, it is hypothesized that administration of GLP-1R agonists may elevate the risk of breast cancer progression in these patients, thus necessitating particular caution in clinical management [101]

The mechanism appears to involve the nitric oxide (NO) system

If you have established atherosclerotic cardiovascular disease, your healthcare provider will likely recommend one of these agents with proven cardiovascular benefit

In an additional, 24-week, placebo-controlled factorial study of initial therapy with sitagliptin in combination with metformin, the adverse reactions reported (regardless of investigator assessment of causality) in 5% of patients are shown in Table 2

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