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They act as repositories for the gradual release of active substances and can penetrate the lipid bilayers of the epidermis and stratum corneum (SC) through individual phospholipids [7, 8]

The response time after having a question was less that a 24hr period

Both Complete Response Letters were due to manufacturing and supplier issues

Critical limitations identified in the systematic review include predominant use of small rodent models (primarily rats), short follow-up periods relative to human healing timelines, variable dosing regimens complicating dose-response assessment, and lack of standardized outcome measures across studies

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Cheung, A., Podgorny, P., Martinez, J