The jump from 0.5 mg to 1.0 mg is the largest proportional increase in the entire titration schedule, doubling your dose again
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However, homocysteine-lowering trials have produced equivocal results regarding the prevention of cognitive deterioration in this population
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On the other hand, metabolic syndrome (MetS) is a constellation of symptoms that implies a higher risk for CVD and type 2 diabetes (T2D), increasing the morbidity and mortality of these patients