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The treatment regimen involved a 12-week lead-in period followed by a week intensive lifestyle intervention, promoting a mean body weight loss that not only exceeded results seen with placebo but also offered a new avenue for managing weight-related comorbidities such as chronic kidney disease, and obstructive sleep apnea

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While it is not known if semaglutide has the same effect in humans, people with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2) should not take the medication

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Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma