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Kukadia and Venables both say they would like them banned in the UK

10.1016/j.seizure.2010.12.006 Seizure 3 AhmadzadehM.EsmaeilzadehZ.KhezriM

If nausea arises when GLP-1 RA plasma concentrations are at their peak, then continuous exposure to GLP-1 RAs may lead to tachyphylaxisa reduced response to the drug over timeresulting in fewer gastrointestinal symptoms after long-term use [20]

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Cancer Res 59 : 35883591 Zhang L, Kashanchi F, Zhan Q, Zhan S, Brady JN, Fornace AJ, Seth P, Helman LJ (1996) Regulation of insulin-like growth factor II P3 promotor by p53: a potential mechanism for tumorigenesis

Effects of GLP-1 receptor agonist on changes in the gut bacterium and the underlying mechanisms