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Questions related to the technical aspect of the research objectives and awards specifically related to a topic should be emailed to [email protected]

Why this matters for your business: Clients who've tried retinoids, minoxidil, or finasteride and stalled out or who can't tolerate the side effects are exactly the clients searching for a mechanism-based alternative

Fluctuating serotonin levels have recently been implicated in the after-effects of STN DBS due to data reporting that (1) cognitive and depressive symptoms develop after stimulation and (2) anti-Parkinsonian drugs reduce serotonin in the prefrontal cortex and hippocampus, and (3) selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine enhance responsiveness to neurostimulation [371,373,373]

A multicenter trial in Alzheimers disease found no benefit on cognitive or functional outcomes while shifting some biomarkers, a smaller trial in healthy older adults reported improved memory and hippocampal connectivity, and the overall assessment is that it is unlikely to help most healthy adults and that the evidence is not conclusive

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In a post-hoc subgroup analysis, a 90-day mortality benefit was observed in patients from the USA, raising the possibility that geographic location, timing of treatment, or other factors may modify the therapeutic effect