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Then someone mentions a weight loss drug, of all things, that made their joint pain disappear

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Symptoms of hypothyroidism may include: Tiredness Weight gain Cold intolerance Joint and muscle pain Dry skin Thinning hair or hair loss Irregular or heavy periods Problems with fertility Slow heart rate Depression Both drugs are used to treat hypothyroidism due to various causes, including primary (low thyroid hormone caused by the destruction of the thyroid gland, such as by a condition called Hashimotos thyroiditis), secondary (underactive thyroid due to the pituitary gland), or tertiary (underactive thyroid due to the hypothalamus) congenital (inherited) or acquired hypothyroidism

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(34221552) Other mechanisms might include reduced calcium entry into neurons and enhanced GABA activity