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IL-6 has a complicated and often contradictory role based on its cell or tissue of origin, concentration, and signaling pathways spanning from pro- to anti-inflammatory roles especially with regard to obesity and inflammation 39,40,41,42,43

1,3 *Efficacy estimand: This analysis was not included in the statistical testing hierarchy, and as such, is hypothetical and was not controlled for multiplicity

doi: 10.1074/jbc.273.14.8225, 69

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