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Both vitamin B12 deficiency and folate deficiency are more common in older people, affecting around 1 in 10 people aged 75 or over and 1 in 20 people aged 65 to 74

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Formulated with a combination of copper (Cu) and the tripeptide GHK (Gly-His-Lys), GHL-Cu offers a scientifically advanced approach to promoting youthful, radiant skin

doi: 10.1146/annurev.pp.41.060190.002323 50 LiuL.LiJ

Through an initial exploration of the SAR, we found that modifications of the ethoxy group were well tolerated, resulting in an increased affinity, whilst substitution of the sulfonic acid moiety was less well tolerated, mostly by negatively affecting the aqueous solubility of the fragments

Both are acceptable approaches depending on clinical context