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Cell Rep (2018) 24(10):277383 e6

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doi: 10.1002/mpo.10135 26 ChoiISKookHHanDKBaekHJJungSTLeeJHet al

For instance, an elevated ROS production by the respiratory chain is observed in obesity as a response to metabolic overload caused by excess macronutrients and increased substrate availability ( Several enzymatic and non-enzymatic defence mechanisms that guard cells against free radical damage have been identified in different cellular localizations, including mitochondria, plasma membrane, endoplasmic reticulum, peroxisomes, and cytosol

3.4 Time to onset analysis With the exception of lixisenatide, which was excluded from the analysis due to insufficient validated data, the time to onset of metabolic and nutritional disorders was summarized in Figure 3